Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs.
نویسندگان
چکیده
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
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عنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 92 12 شماره
صفحات -
تاریخ انتشار 1995